David Ron received his medical degree from the Technion in Haifa, Israel (1980). After completing clinical training in Internal Medicine at Mount Sinai Hospital in New York City (1987), and Endocrinology and Metabolism at the Massachusetts General Hospital in Boston (1989), he undertook post-doc training with Joel Habener at Harvard Medical School. In 1992 he took a faculty position at New York University School of Medicine establishing a lab at the Skirball Institute of Biomolecular Medicine focused on the cellular adaptations to unfolded protein load, especially as they pertain to mammalian pathophysiology. In 2009 he relocated to the University of Cambridge’s Clinical School where he presently serves as Professor of Cellular Pathophysiology and Clinical Biochemistry.
His research program seeks to understanding how eukaryotic cells adapt to changing levels in the load of unfolded proteins that are presented to the folding machinery in the endoplasmic reticulum, the gateway to the secretory pathway. This problem extends from the molecular basis of the intracellular signal transduction pathways to the biological consequences of endoplasmic reticulum stress in whole organisms. The latter is relevant to our emerging understanding of the links between protein misfolding and diseases of aging and the importance of protein folding homeostasis to health.