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Phase Transitions in Biology and Disease

2 - 3 May 2017, Leuven, Belgium
Phase Transitions in Biology and Disease - campaign visual
Faculty Club - venue
Faculty Club - venue
Faculty Club - venue
Faculty Club - venue
Old Market - Leuven
Old Market - Leuven
Totem by Jan Fabre - Leuven
Totem by Jan Fabre - Leuven
Old Market Leuven
Poster session - Leuven
Poster session - Leuven
Poster session - Antwerp
Poster session - Antwerp
Leuven by air
Leuven by air
Phase Transitions in Biology and Disease

In the past few years the concept of protein phase transitions has taken the field of cell biology and protein biochemistry by storm. The initial discoveries were met with great enthusiasm as they provide the rationale for the formation of membrane-less organelles, such as stress granules, processing bodies and RNP bodies, in biology and human disease. By studying the biophysics of the involved proteins, it was shown that this process could be modeled by liquid-liquid demixing, also making the connection of such liquid compartments to characteristic protein aggregations observed in numerous neurodegenerative diseases. Whereas this is perhaps one of the biggest breakthroughs in these fields in recent years, key questions remain to be addressed towards the goal of fully understanding their functional properties in the cell and targeting them in proteinopathies.

This meeting gathers leading figures from the phase transition and protein aggregation field, whose work has spearheaded the recent developments. Where have we come from? Where are we now? And moreover, which direction the field is heading? Come join us on this exciting meeting!

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Confirmed speakers

Program

Day 1 - Tuesday, 02 May, 2017

11:00
13:30
Registration - Lunch
Plenary session 1 day 1
13:30
13:45
Welcoming Remarks

Wim Robberecht

Vice rector Biomedical Sciences KU Leuven; Head KU Leuven Lab of Neurobiology, BE
13:45
14:15
Structural disorder promotes phase separation of C9orf72 dipeptide repeats in ALS
14:15
14:45
Disturbed phase transitions in neurological diseases
14:45
15:15
Visualizing structural details of disordered domain phase separation associated with ALS and cancers
15:15
15:45
Phase separation of a cancer-associated ubiquitin ligase
15:45
16:15
Coffee break
16:15
16:30
Quantitative integrative FRET studies unravel the dynamic structure and the oligomerization of the large GTPase hGBP1 during phase transitions
16:30
16:45
Liquid-liquid phase separation of tau
16:45
17:15
Contributions of RNA Binding Proteins to tau biology and tauopathies
17:15
17:45
Dynamic oligomerization of TDP-43 in health and disease
18:30
19:30
Reception

Day 2 - Friday, 03 May, 2019

Plenary session 1 day 2
09:00
09:30
RNP Granules in Health and Disease
09:30
10:00
RNP granules: how they form, age, and cause disease

Simon Alberti

Max Planck Institute of Molecular Cell Biology and Genetics, DE
10:00
10:30
A solid state conceptualization of information transfer from gene to message to protein
10:30
11:00
Coffee break
11:00
11:15
Amyloid-like Assembly of a Cellular Compartment
Selected from abstracts
11:15
11:30
Reduction of ataxin 2 extends lifespan and rescues ALS-associated pathology in TDP-43 mice
11:30
11:45
Phase transition and aggregation of FUS are promoted by loss of arginine methylation and impaired binding to the nuclear import receptor Transportin
Selected from abstracts
11:45
12:00
Increase in protein abundance causes ribonucleoprotein granule formation
12:00
14:00
Lunch + Poster session
Plenary session 2 day 2
14:00
14:30
Synthetic Functional Amyloids
14:30
15:00
Fuzziness in higher-order assemblies and its role in biological phase transitions
15:00
15:15
Structures reveal kinked beta-sheet interaction motifs between low-complexity regions distinguish dynamic membraneless organelles from amyloid fibrils
15:15
15:30
Prion replication in the mammalian cytosol: Functional regions within a prion domain that drive induction, propagation and inheritance
15:30
16:00
Coffee break
16:00
16:30
Reversing aberrant phase transitions connected to ALS
16:30
17:15
Uncovering sequence-encoded phase diagrams of intrinsically disordered proteins

Organizing committee

Joost Schymkowitz

VIB-KU Leuven Center for Brain & Disease Research, BE

Frederic Rousseau

VIB-KU Leuven Center for Brain & Disease Research, BE

Ludo Van Den Bosch

VIB-KU Leuven Center for Brain & Disease Research, BE

Peter Tompa

VIB-VUB Center for Structural Biology, BE

Elke Bogaert

VIB-KU Leuven Center for Brain & Disease Research, BE

Steven Boeynaems

VIB-KU Leuven Center for Brain & Disease Research, BE

Lien Houbrechts

VIB-KU Leuven Center for Brain & Disease Research, BE

Abstracts

The full list of abstracts will be available on 25-04-2017 until 17-05-2017
This list will only be available for registered attendees of the event.

Attendees

The full list of attendees will be available on 25-04-2017 until 17-05-2017
This list will only be available for registered attendees of the event.