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Tumor Heterogeneity, Plasticity and Therapy

2021 Q1 or Q2, Leuven Belgium
Tumor Heterogeneity, Plasticity and Therapy - campaign visual
Jubileumzaal - Venue picture
Martelaren Square - Leuven (Copyright Tobias - Cornille)
Martelaren Square - Leuven (Copyright Tobias - Cornille)
Old Market - Leuven
Old Market - Leuven
Conference dinner - Faculty Club
Conference dinner - Faculty Club
Grote Markt - Leuven
Grote Markt - Leuven
Totem by Jan Fabre - Leuven
Totem by Jan Fabre - Leuven
Sponsor booths - Leuven
Sponsor booths - Leuven
Poster session - Ghent
Poster session - Ghent
Tumor Heterogeneity, Plasticity and Therapy
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Due to the Corona virus the organizing committee has made the decision to postpone the Tumor Heterogeneity, Plasticity and Therapy conference to the first half of next year. This is very unfortunate, but as a research institute VIB has to act responsibly. Together with the organizing committee we will look for a venue and a date and we hope to send you more information about a potential new conference date soon.


We are pleased to announce the first edition of the VIB Conference ‘Tumor heterogeneity, plasticity and therapy’. This international conference will take place in the beautiful historic city of Leuven.

Tumors are complex and evolving ecosystems composed of a wide variety of cell types, in addition to the cancer cells themselves. Increasing evidence indicates that the bi-directional interplay between tumor cells and their tumor microenvironment shape tumor evolution and therapy resistance.

Within a tumor, many cancer cells differ from each at the (epi-)genomic, transcriptional and proteomic level, as well as phenotypically and functionally. Tumor heterogeneity represents a major hurdle for therapy, which may only target a subset of tumor cells. In addition, cancer cell plasticity permits rapidly adaption to therapeutics and development of tolerance and resistance, presenting additional challenges for both targeted and immunotherapies.

During this conference a range of world leaders from academia and industry will discuss the latest developments in basic research, translational and clinical research and therapeutic avenues, in the following sessions:

  • Plasticity in initiation, progression and metastasis
  • Heterogeneity and reprogramming of the tumor immune- and microenvironment
  • Adaptation and resistance to targeted therapies
  • Adaptation and resistance to immunotherapies

Information for poster submissions:
The format for your poster should be: A0 (841 x 1189 mm / 33.1 x 46.8 in), portrait orientation. The deadline for the poster abstracts is currently extended. The best poster will win the Nature Poster Prize.

Travel Grants
The travel grant deadline has passed. The selection has been announced. When you’re awarded with a travel grant you will receive a practical email containing the next steps. Note that being awarded a travel grant does not mean being registered for the conference. Travel grants awarded before the COVID-19 situation can be used for the postponed edition.

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Confirmed speakers

Johanna Joyce
Joyce Johanna - profile picture
Johanna Joyce

Johanna Joyce

Department of Oncology, University of Lausanne, Ludwig Institute for Cancer Research, CH
Leila Akkari
Akkari Leila - profile picture
Leila Akkari

Leila Akkari

Division of Tumor Biology & Immunology, Oncode Institute. Netherlands Cancer Institute (NKI), NL
Mark Dawson
Dawson Mark - profile picture
Mark Dawson

Mark Dawson

Sir Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne, AU
Zemin Zhang
Zhang Zemin - profile picture
Zemin Zhang

Zemin Zhang

BIOPIC, College of Life Sciences, and Beijing Advanced Innovation Center for Genomics, Peking University, CN

Program

Preconference reception - Wednesday, 13 May, 2020

19:00
20:00
Reception at Historical Leuven Town hall
Address: Grote Markt 9, 3000 Leuven

We proudly welcome those of you arriving a day in advance of the conference for a reception in the beautiful Leuven City Hall. The Mayor of Leuven will tell you a bit about the city and you will get to taste some of those famous Belgian beers.

The town hall is Leuven's pride and joy. Moreover, it's one of the best-known Gothic town halls worldwide. It took three architects and thirty years to build it. Leuven's 'Hall of Fame' features 236 statues, which were only added to the façade after 1850.

Make sure to add the free prefconference Reception ticket to your registration.

Day 1 - Thursday, 14 May, 2020

Address: Promotiezaal KU Leuven, Naamsestraat 22, 3000 Leuven

08:45
09:15
Registration and welcome coffee
09:15
09:20
Welcome
Session 1 - Plasticity & initiation/progression and metastasis (including CTCs)
09:20
09:55
SCLC and vasculogenic mimicry - a route to metastasis?

Caroline Dive

CRUK Manchester Institute, The University of Manchester, UK
09:55
10:30
Dissecting the metastatic microenvironment
10:30
11:00
Coffee break
11:00
11:35
Metastasis metabolism - You are what you eat
11:35
12:10
Cancer Genomes in 3D
12:10
12:25

Presenter to be announced

Selected from abstracts
12:25
13:15
Lunch
13:15
14:15
Poster session
Session 2 - Heterogeneity and reprogramming of the Tumor (immune) microenvironment
14:15
14:50
Immune contexture and tumor evolution in the era of immunotherapy

Jerome Galon

INSERM & Laboratory of Integrative Cancer Immunology, Sorbonne Universite, FR
14:50
15:25
Exploring and Exploiting the Tumor Microenvironment

Johanna Joyce

Department of Oncology, University of Lausanne, Ludwig Institute for Cancer Research, CH
15:25
15:40

Presenter to be announced

Selected from abstracts
15:40
16:10
Coffee break
16:10
16:45
Neuronal activity promotes the progression of glial malignancies
16:45
17:20
Dynamic Properties of Tumor-Infiltrating Immune Cells Revealed by Single Cell Sequencing

Zemin Zhang

BIOPIC, College of Life Sciences, and Beijing Advanced Innovation Center for Genomics, Peking University, CN
17:20
17:55
Closing talk
Epigenetic influence of our (fatty) diet on metastatic-initiating cells
17:55
19:00
Reception
20:00
22:30
Conference dinner

Day 2 - Friday, 15 May, 2020

Address: Promotiezaal KU Leuven, Naamsestraat 22, 3000 Leuven

08:45
09:15
Welcome coffee
Session 3 - Adaptation and Resistance to targeted therapies
09:20
09:55
Tumor cell plasticity as a challenge for targeted therapies in colorectal cancer
09:55
10:30
Heterogeneity and plasticity in head and neck cancer
10:30
11:00
Coffee break
11:00
11:35
Starvation and pseudo-starvation as drivers of phenotypic plasticity

Colin Goding

Ludwig Institute for Cancer Research, University of Oxford, UK
11:35
12:10
Understanding the molecular evolution of tumors during therapy
12:10
12:25

Presenter to be announced

Selected from abstracts
12:25
13:15
Lunch
13:15
14:15
Poster session
Session 4 - Adaptation and Resistance to immuno-therapies (including influence of microbiome)
14:15
14:50
Chromosomal instability and genome plasticity in cancer evolution, immune evasion and metastasis
14:50
15:25
Targeting the epigenome in cancer

Mark Dawson

Sir Peter MacCallum Department of Oncology & Centre for Cancer Research, University of Melbourne, AU
15:25
15:40

Presenter to be announced

Selected from abstracts
15:40
16:10
Coffee break
16:10
16:45
Primary and secondary resistance to cancer immunotherapy
16:45
17:20
Harnessing the potential of myeloid cells in brain and liver cancer treatment: a matter of genetics, time and combination

Leila Akkari

Division of Tumor Biology & Immunology, Oncode Institute. Netherlands Cancer Institute (NKI), NL
Closing Talk
17:20
17:55
Ordering Chaos: Delineating The Cell-Intrinsic Metabolic Signals That Direct Cell Differentiation

Erika Pearce

Max Planck Institute of Immunobiology and Epigenetics, DE
17:55
18:00
Closing remarks

Organizing committee

Abstracts

Submit your abstract for this event

Due to the postponement of the conference, the abstract deadline is currently extended until the end of this year. Once the new dates for the conference are know, the exact end date will be published here. 

Abstract submission closing date:   Friday, 13 November, 2020
Submit an abstract
The full list of abstracts will be available on 01-01-2021 until 15-01-2021
This list will only be available for registered attendees of the event.

Attendees

The full list of attendees will be available on 01-01-2021 until 15-01-2021
This list will only be available for registered attendees of the event.