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Cancer Biology

Tumor Heterogeneity, Plasticity and Therapy (3rd edition)

10-12 December 2025, Leuven, Belgium
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Tumor Heterogeneity, Plasticity and Therapy (3rd edition)

Tumor Heterogeneity, Plasticity and Therapy (3rd edition)
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It is with great pleasure that we announce the third edition of the VIB conference ‘Tumor heterogeneity, plasticity and therapy’. Growing evidence highlights the bi-directional interactions between tumor cells and their microenvironment as key drivers of tumor evolution and therapy resistance.

Within a tumor, cancer cells exhibit significant variability, which poses a major challenge for therapy, as treatments often target only a subset of tumor cells. Furthermore, cancer cell plasticity enables rapid adaption to therapeutics and the development of tolerance and resistance, presenting additional challenges for both targeted and immunotherapies.

21 distinguished invited speakers will share their latest research and insights in the following topics:

  • Plasticity and initiation
  • Progression and metastasis
  • Therapy resistance (fundamental)
  • Therapy resistance (translational/clinical)

During the event, we anticipate vibrant discussions and collaborations that will not only highlight recent breakthroughs but also pave the way for transformative advancements in the fight against cancer

Abstracts & travel grants
Submit your abstract for a poster and/or oral presentation before the deadline of 8 October 2025. The best presentation will receive the Nature Poster Prize.

We offer 4 travel grants to international junior scientists, which will reimburse travel costs up to 400 Euros. The deadline to participate is 17 September 2025.

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Confirmed speakers

Program

Day 1 - Wednesday, 10 December, 2025

13:15
13:45
Registration & Coffee
13:45
13:55
Welcome word by Jean-Christophe Marine
13:55
14:30
Opening keynote

Chair: Cédric Blanpain

13:55
14:30
Unraveling the complexity of cancer ecosystems

Johanna Joyce

University of Lausanne, Ludwig Institute for Cancer Research, CH
Keynote speaker
14:30
18:10
Session 1: Plasticity and initiation

Chairs: Cédric Blanpain & Jean-Christophe Marine

14:30
15:00
Intratumoural heterogeneity promotes small cell lung cancer progression
15:00
15:30
Fate versus free will; how does the environment shape early tumour survival?
15:30
16:00
Unlocking the barriers to tumour development in the mouse colon
16:00
16:15
Revealing novel cancer cell-intrinsic immunogenic meta-programs in glioblastoma

Francisca Borges

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, BE
Selected from abstracts
16:15
16:45
Coffee break
16:45
17:00
The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

Simon Durand

Cancer Research Center of Lyon, FR
Selected from abstracts
17:00
17:30
Clonal hematopoiesis and precision prevention of myeloid neoplasms
17:30
18:00
In vivo veritas - Unveiling tumor dependencies through CRISPR screens
18:00
18:05
Deciphering cell-cell interactions at scale
Sponsored talk
18:05
18:10
Meet the Nature editors
18:10
19:30
Poster session 1 & Reception

Day 2 - Thursday, 11 December, 2025

08:30
09:00
Welcome coffee
09:00
09:35
Keynote 2

Chair: Barbara Marte

09:00
09:35
Genetic and non-genetic mechanisms of clonal dominance and therapeutic resistance in cancer
09:35
12:40
Session 2: Progression and Metastasis

Chairs: Barbara Marte & Jan Remsik

10:05
10:35
Hippo signaling in liver cancer
10:35
10:50
Unraveling the role of microglia-secreted lipids on glioblastoma invasion

Carla Pallarés Moratalla

VIB-Center for Cancer biology (KU Leuven), BE
Selected from abstracts
10:50
10:55
Unveiling tumor heterogeneity with BD Rhapsody™ Single-Cell Multiomics System

Alon Rothfusz

BD Biosciences Benelux, NL
Sponsored talk
10:55
11:20
Coffee break
11:20
11:50
Single-cell and spatial analysis of heterogeneity in head & neck cancer
11:50
12:20
Microbial niches across GI-tract cancers: multi-omics and single-cell spatial insights

Susan Bullman

University of Texas; James P. Allison Institute; MD Anderson Cancer Center, US
12:20
12:35
Interrupting human leptomeningeal metastasis with deferoxamine

Philipp Weiler

Memorial Sloan Kettering Cancer Center, US
Selected from abstracts
12:35
12:40
End-to-End Solutions for Cancer Research and Therapy Development

Min Wen Ku

Application Scientist at VectorBuilder, UK
Sponsored talk
12:40
13:40
Lunch
13:30
14:30
Poster session 2
14:30
18:00
Session 3: Therapy resistance (fundamental)

Chairs: Damya Laoui & Diether Lambrechts

14:30
15:00
Targeting the microbiome to promote health and end cancer
15:00
15:30
Epigenetic plasticity at the crossroads of inflammation and pancreatic tumorigenesis
15:30
16:00
Understanding and Overcoming the Evolution of Therapy Resistance
16:00
16:15
Simple cell geometry metrics track cancer cell diversity and plasticity and inform combination therapy strategies

Hadrien De Blander

Center for Cancer Biology, VIB, BE; Department of Oncology, KULeuven, BE
Selected from abstracts
16:15
16:45
Coffee break
16:45
17:00
Unravelling heterogeneity in response to engineered T-cell immunotherapy using patient-derived cancer organoids

Britt Vervoort

Princess Maxima Center, NL; Oncode Institute, NL
Selected from abstracts
17:00
17:30
Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD
17:30
18:00
Targeting the Hippo Pathway in Cancers
18:00
19:30
Guided tour

Day 3 - Friday, 12 December, 2025

08:30
09:00
Welcome coffee
09:00
12:30
Session 4: Therapy resistance (translational/clinical)

Chairs: Ulrike Harjes & Olaf Klingbeil

09:00
09:30
Plasticity, therapy resistance and immune evasion in metastatic colorectal cancer
09:30
10:00
Epigenomic evolution of breast cancers at single-cell resolution
10:00
10:30
A portfolio of cellular immunotherapies for ALK-driven cancers

Roberto Chiarle

Boston Children’s Hospital/Harvard Medical School, US & University of Torino, IT
10:30
10:45
Microbiota-tumor molecular-mimicry enhance response to immunotherapy in patients with melanoma.

Luigi Nezi

Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, IT
Selected from abstracts
10:45
11:15
Coffee break
11:15
11:45
A multiscale framework of diffuse glioma remodeling of neuronal circuits
11:45
12:15
From nuclear architecture to leukemia cures: roles of PML and sumoylation
12:15
12:30
Synthetic super-enhancers enable selective expression of anti-cancer payloads for viral gene therapy

Steven Pollard

University of Edinburgh & Trogenix Ltd, GB
Selected from abstracts
12:30
12:45
Closing words by Diether Lambrechts
12:45
13:30
Lunch

Organizing committee

Abstracts

Poster information
The format for your poster should be: A0 (841 x 1189 mm / 33.1 x 46.8 in), portrait orientation. All accepted poster submissions will have a chance to win the Nature Poster Prize!

The full list of abstracts will be available on 10-11-2025 until 12-03-2026
This list will only be available for registered attendees of the event.

Attendees

The full list of attendees will be available on 10-11-2025 until 12-03-2026
This list will only be available for registered attendees of the event.