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Anne-Claude Gingras

The Lunenfeld-Tanenbaum Research Institute, CA

Anne-Claude Gingras received her PhD in 2001 from the Sonenberg lab at McGill University for her studies on translational control, and in particular on the regulation of translation initiation by the PI3K-Akt-mTOR pathway. She did her postdoctoral training in the laboratory of Ruedi Aebersold at the Institute for Systems Biology in Seattle where she developed approaches using mass spectrometry to identify protein-protein interactions amongst signalling molecules. She joined the Lunenfeld-Tanenbaum Research Institute in 2005 where she is now a Senior Investigator, a Canada Research Chair in Functional Proteomics and the Lea Reichmann Chair in Cancer Proteomics. She was cross-appointed in the department of Molecular Genetics at the University of Toronto in 2006 where she is currently an Associate Professor. Her lab focuses on the study of signalling pathways using systematic approaches and the development of quantitative proteomics technologies, both experimental and computational. In collaboration with Alexey Nesvizhskii (U Michigan) and Mike Tyers (IRIC, U Montreal), she has developed a series of software tools to store, track and analyse mass spectrometry data, including powerful tools to identify true interactors from background contaminants and to visualize the data. More recently, she has been adapting her workflows for identifying dynamic protein-protein interactions to data independent mass spectrometry acquisition. She also continues her studies on the characterization of the STRIPAK complex, a signalling complex containing kinase and phosphatase activities, which is linked to both vascular diseases (Cerebral Cavernous Malformations through CCM3) and cancer (through an association with the Hippo kinases).