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Dominic Grün

Max Planck Institute of Immunology and Epigenetics, DE
Biography

After obtaining his PhD in theoretical physics Dominic Grün transitioned into the field of computational biology. During his postdoctoral period, he worked with Nikolaus Rajewsky on post-transcriptional gene regulation during development and in pluripotent stem cells, and later moved on to the laboratory of Alexander van Oudenaarden where he developed methods for the computational analysis of single-cell RNA-sequencing data. Since 2015 he is leading a combined experimental and computational group at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, where he investigates the processes of cell fate decision and cell state plasticity at single-cell resolution in a variety of systems, in particular, across diverse lineages of the immune system and in the liver. He is fascinated by the complexity of gene regulatory networks which robustly control differentiation hierarchies, starting from a multipotent cell and giving rise to highly organized tissues with a multitude of cell types. His current work focusses on investigating the interplay of cell-intrinsic processes, in particular, gene expression noise, and extrinsic signals from the microenvironment in the control of stem cell differentiation. Towards this goal, his group integrates a variety of single-cell sequencing techniques with spatial in situ imaging and computational modelling, applied to mouse models and human patient material. He is an active member of the Human Cell Atlas and the LifeTime consortium.

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