Hanlee P. Ji, M.D., is an associate professor in the Division of Oncology, Department of Medicine, at Stanford University School of Medicine. He is also the senior associate director of the Stanford Genome Technology Center, facilitating genome center projects geared toward clinical applications and helping guide the center toward the application of novel technologies to clinical problems. In addition, Dr. Ji is an attending oncologist and clinical geneticist at the Stanford Cancer Center and Palo Alto Veteran’s Administration Medical Center. He completed clinical training at the University of Washington and Stanford University, and he attended the Johns Hopkins University Medical School and Reed College.
He was an HHMI Medical Fellow in 1991–1992 and received the HHMI Physician-Scientist Early Career award in 2008. His research is focused on characterizing the impact of combinatorial mutations and other genetic variants on cancer clinical phenotype.
The specific goals of his research program are:
1) developing innovative open-access strategies of deconstructing cancer genomes through sequencing,
2) identifying critical genetic events in colorectal cancer and other gastrointestinal malignancies influencing tumor behavior, and
3) translating those findings into prognostic and predictive genetic biomarkers that can be used clinically. To achieve these goals, his group is pioneering new approaches and the development of genomic technologies to accomplish highthroughput and high-resolution somatic mutation analysis of cancer. This effort relies on integrating novel molecular assays, developing next-generation sequencing technology, and creating bioinformatics to handle large-scale sequence data analysis.
Dr. Ji also has an active translational research program addressing key questions in the management of colon cancer and others.