Luc Buée

Luc Buée is a French scientist (Directeur de Recherche au CNRS - DRCE CNRS), Director of the Lille Neuroscience & Cognition Research Centre and Head of the Inserm laboratory «Alzheimer & Tauopathies» at the University of Lille, France. Located on the Lille hospital campus, his laboratory belongs to the Lille Centre of Excellence in Neurodegenerative disorders (LiCEND - CoEN) and is also part of the LabEx DISTALZ (National consortium on Alzheimer's disease).

Luc Buée has been working on Alzheimer's disease and related disorders for more than thirty years. He began his work on the role of proteoglycans in Alzheimer's disease during his PhD training at Mount Sinai Medical Center, New York. He made some of the pioneering neuropathological observations on microvasculature abnormalities in neurodegenerative disorders. He was involved in the initial biochemical characterisation of tau aggregates in certain neurodegenerative disorders (tauopathies barcode). He then developed experimental models to better understand the role of post-translational modifications in tau aggregation and secretion. These experimental models are now widely used to evaluate therapeutic strategies for tauopathies (immunotherapy, small molecules, non-drug therapy...). With his team, he has also discovered numerous non-microtubular functions of the tau protein. He is currently working on the pathophysiological consequences of neurofibrillary degeneration and their links with amyloid pathology and neuroinflammation in Alzheimer's disease. His group has been/is also involved in different international consortia.

Luc Buée is also involved in different scientific committees. Since October 2019, he is the President of the French Society for Neuroscience (Société des Neurosciences).