Nanobodies (Hybrid 2nd edition)
8-10 September 2021 - Virtual & Brussels, Belgium
Nanobodies (Hybrid 2nd edition)
Nanobodies (Hybrid 2nd edition)
Trends in Structural Biology satellite meeting on 10 september
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The discovery of nanobodies® by Raymond Hamers in the 1980s and the further development of the technology by Serge Muyldermans and Jan Steyaert fundamentally changed approaches in different areas of medicine. Nanobodies® are very useful in the diagnosis and treatment of serious and life-threatening diseases.
As nanobodies® were born at the University of Brussels, the VIB-VUB Center for Structural Biology is very honored to organize the hybrid second edition of the Nanobody conference. This meeting series was launched in September 2019 at the University of Bonn by Florian Schmidt and Paul-Albert König.
During the 2day conference on 8-9 September 2021, leaders in the field will present their latest findings in sessions focused on:
- Nanobody engineering
- Innovative research tools
- Nanobodies® in diagnostics, imaging and microscopy
- Nanobodies® as therapeutic molecules
- Nanobodies® as anti-infectious agents
On Friday 10 September, a satellite event ‘Trends in structural biology’ will be held.
Recorded talks
If you're registered for the conference & logged-in in the website here (right top corner), the video icon will appear.
Check the compilation video here.
Attending a VIB Conference safely in times of COVID-19
VIB Conferences will follow the rules set up by the Belgium Government, you can read all the details regarding attending a VIB Conference here.
What to expect from this hybrid event
The scientific program (presentations, Q&A’s, and poster sessions) will be available for both live and virtual audiences. The virtual platform also offers several ways of interacting with each other through (video) chat. On top of this there will be live poster presentations for those attending the event in Brussels.
Information for poster presenters
The format for your (live) poster should be: A0 (841 x 1189 mm / 33.1 x 46.8 in), portrait orientation.
The format for your (virtual) poster should be: 4 slides in 16:9 format + a recorded video of your talk.
The best abstracts will have a short talk slot in the plenary program. The 2 best posters will win the Poster prize!
Confirmed speakers
Program
Day 1 - Wednesday, 08 September, 2021
08:30
09:00
Registration & welcome coffee
09:00
09:10
Welcome
Jan Steyaert
VIB-VUB Center for Structural Biology, BE
09:10
09:40
Opening talk
09:10
09:40
Selection technologies and dedicated tailoring to broaden application range of Nanobodies.
Serge Muyldermans
VUB, BE
09:40
12:10
Nanobodies in diagnostics, imaging and microscopy
Chair: Ulrich Rothbauer
09:40
10:10
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable and mutation-tolerant nanobodies
Dirk Görlich
Max Planck Institute for Biophysical Chemistry, Göttingen, DE
10:10
10:40
Sensing and modulating opioid receptor signalling by nanobodies
Miriam Stöber
University of Geneva, Faculty of Medicine, CH
10:40
11:10
Coffee break
11:10
11:25
Nanobody-based immunoassays: addressing the need for improved sensitivity and specificity in medical diagnostics
Francisco Javier Morales Yanez
VUB & Institute of Tropical Medicine, Antwerp, BE
Selected from abstracts
11:25
11:40
A convenient labeling strategy for the preparation of bimodal tracers carrying Tc-99m and IRDye800CW for intraoperative tumor recognition and delineation
Noemi Declerck
Vrije Universiteit Brussel, BE
Selected from abstracts
11:40
12:10
Noninvasive imaging of immune responses
Mohammad Rashidian
Dana Farber Cancer Institute, US
12:10
12:15
An Introduction to GenScript Biotech
Nicholas Gouw
Genscript - Marketing Specialist, NL
Sponsored talk
12:15
13:00
Lunch
13:00
14:00
Poster session 1 (Live @ Brussels)
14:00
17:45
Nanobodies as therapeutic molecules and anti-infectious agents
Chair: Florian Schmidt
14:00
14:30
Old monkeys, new tricks: use of an IL-1-based AcTakine to drive T cell immunity
Bram Van Den Eeckhout
VIB-UGent Center for Medical Biotechnology, BE
14:30
15:00
Therapeutic targeting human and viral chemokine receptors by nanobodies
Martine Smit
Vrije Universiteit Amsterdam, NL
15:00
15:15
Identification and In Vivo Validation of Brain-penetrating Nanobodies
Maarten Dewilde
VIB Center for Brain & Disease Research, BE; KU Leuven, BE
Selected from abstracts
15:15
15:30
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Paul-Albert Koenig
Core facility nanobodies, University of Bonn, DE
Selected from abstracts
15:30
15:35
Addressing the reproducibility crisis with high-level antibody production and validation
Klaus Henrick
Proteintech Group, DE
Sponsored talk
15:35
16:00
Coffee break
16:00
16:30
Fighting coronavirus spikes with nanobodies
Xavier Saelens
VIB-UGent Center for Medical Biotechnology, BE
16:30
17:00
Broad reactivity nanobodies against influenza hemagglutinin and their applications
Simon Hufton
The National Institute for Biological Standards and Control, UK
17:00
17:45
Workshop: International database on nanobodies
Moderated by Jan Steyaert
17:45
18:45
Reception
20:00
Conference dinner
Additional fee - more info
Day 2 - Thursday, 09 September, 2021
08:45
09:10
Coffee
09:10
09:40
Opening talk
09:10
09:40
The story of caplacizumab, the first NANOBODY® therapeutics on the market
Carlo Boutton
Ablynx (Sanofi company), BE
09:40
12:10
Innovative research tools
Chair: Martine Smit
09:40
10:10
Novel mechanisms of nanobody binding: From light controls to active site melting
Jose Avalos
Princeton University, US
10:10
10:40
Spin-labeled nanobodies as conformation reporters of membrane proteins in cells
Enrica Bordignon
Ruhr University Bochum, DE
10:40
11:10
Coffee break
11:10
11:40
Non-invasive immune imaging and cancer therapy using human PD-L1 nanobodies
Karine Breckpot
VUB, BE
11:40
11:55
Have the cake and eat it too: NestLink allows the pre-clinical screening of over 100 drug-like nanobodies in a single animal
Justin Walter
University of Zurich, CH
Selected from abstracts
11:55
12:10
Integrative proteomics identifies thousands of distinct, multi-epitope, and high-affinity nanobodies
Zhe Sang
University of Pittsburgh, US
Selected from abstracts
12:10
12:15
Writing the Future of Biologics - Introduction to Twist Biopharma
Leonie Alten
Scientific Development Manager, SynBio, Twist Bioscience, DE
Sponsored talk
12:15
12:45
Lunch
12:45
13:45
Poster session 2 (Virtual)
13:45
14:30
2 workshop sessions
Workshop: Synthetic versus immune libraries
Moderated by Markus Seeger & Serge Muyldermans
Workshop: How to modify nanobodies for imaging purposes
Moderated by Nick Devoogdt & Ulrich Rothbauer
Only live available.
14:45
17:30
Nanobody engineering
Chair: Markus Seeger
14:45
15:15
Nanobodies as tools to interrogate membrane protein structure and function
Andrew Kruse
Harvard Medical School, US
15:15
15:45
Structural biology as guide for nanobodies against covid19
Jim Naismith
The Rosalind Franklin Institute, UK
15:45
15:50
Immunization strategies for generating camelid single-domain antibodies
Jonas Füner
Preclinics - Director, DE
Sponsored talk
15:50
16:15
Coffee break
16:15
16:30
GlycoVHH: a synthetic glyco-engineering approach to increase VHH versatility
Loes Van Schie
VIB-UGent Center for Medical Biotechnology, BE
Selected from abstracts
16:30
16:45
Photocaged Nanobodies for Spatiotemporal Control of Cellular Processes with Light
Henning D. Mootz
Institute of Biochemistry, University of Münster, DE
Selected from abstracts
16:45
17:15
Nanobodies to engineer immunity
Hidde Ploegh
Boston Children’s Hospital, US
17:15
17:35
Closing of the conference
Serge Muyldermans
VUB, BE
17:30
19:00
Social activity Brussels
Day 3 - Friday, 10 September, 2021
09:00
09:30
Registration & coffee
09:30
09:40
Welcome on satellite meeting
09:40
10:10
Opening talk
09:40
10:10
Human GABAA Receptor Structures and Signalling Mechanisms
Radu Aricescu
MRC Laboratory of Molecular Biology, UK
10:10
12:10
Trends in Structural Biology - AM
Chair: Han Remaut
10:10
10:40
Changing the landscape for structural and cellular biology at Diamond
Martin Walsh
Diamond Light Source & University of Oxford, UK
10:40
11:10
Coffee break
11:10
11:40
Targeting the outer membrane insertase with novel antibiotics
Sebastian Hiller
University of Basel, CH
11:40
11:55
The Structural Basis of GPR56/ADGRG1 Regulation in the Central Nervous System
Demet Arac
University of Chicago, US
Selected from abstracts
11:55
12:10
Conformation-specific nanobody selection for structural biology of solute carriers
Benedikt Kuhn
Max Planck Institute of Molecular Cell Biology and Genetics, DE
Selected from abstracts
12:10
12:45
Lunch
12:45
13:45
Satellite poster session
13:45
14:30
Workshop: Applications of nanobodies in Structural biology
Moderated by Jan Steyaert & Han Remaut
14:45
16:15
Trends in Structural Biology - PM
Chair: Jan Steyaert
14:45
15:15
Structural studies of prokaryotic cell surfaces
Tanmay Bharat
Sir William Dunn School of Pathology, University of Oxford, UK
15:15
15:45
A de novo design approach to membrane protein folding
Anastassia Vorobieva
VIB-VUB Center for Structural Biology, BE
15:45
16:15
Coffee break
16:15
16:45
Inverting protein structure prediction models for protein design
Sergey Ovchinnikov
Massachusetts Institute of Technology, US
16:45
17:15
Closing debate: The future of Structural Biology
17:15
17:25
Closing words
Organizing committee
Jan Steyaert
VIB-VUB Center for Structural Biology, BE
Xavier Saelens
VIB-UGent Center for Medical Biotechnology, BE
Han Remaut
VIB-VUB Center for Structural Biology, BE
Nick Devoogdt
Scientific Advisor, Precirix & VUB, BE
Florian Schmidt
University of Bonn, DE
Ulrich Rothbauer
NMI Natural and Medical Science Institute at the University of Tübingen, DE
Markus Seeger
Institut für Medizinische Mikrobiologie, CH
Paul-Albert Koenig
Core facility nanobodies, University of Bonn, DE
Serge Muyldermans
VUB, BE
Evy Vierstraete
VIB Headquarters, BE
Abstracts
The full list of abstracts will be available on 25-08-2021 until 09-10-2021
This list will only be available for registered attendees of the event.
This list will only be available for registered attendees of the event.
Attendees
The full list of attendees will be available on 25-08-2021 until 09-10-2021
This list will only be available for registered attendees of the event.
This list will only be available for registered attendees of the event.
Sponsors
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