The creation of human-derived induced pluripotent stem cells (iPSCs) nearly two decades ago marked a profound milestone, paving the way for groundbreaking humanized models to study the mechanisms underlying various diseases.

Among these, motor neuron disorders such as spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and inherited peripheral neuropathies are no exception to this rule. Starting from patient-derived cells, typically fibroblasts, researchers have used iPSC technology to generate a variety of differentiated cell types. While initial efforts concentrated on obtaining iPSC-derived motor neurons, given their central role in these complicated diseases, researchers have since broadened their scope. More specifically, many other cell types are currently being differentiated and integrated together into increasingly complex 2D and 3D models.

This conference aims to unite scientists from academia as well as industry who use iPSC-derived models to obtain new insights into various motor neuron disorders. During this conference, attendees will present their latest findings using different 2D and 3D iPSC-derived models while addressing both the potential as well as the limitations of this innovative technology.

Leading scientists will share their latest insights in sessions covering the following topics:

• The contribution of iPSC-derived models to the understanding of motor neuron degeneration
• The methodology to differentiate iPSC in different neuronal and non-neuronal cells
• The quality control and reproducibility of iPSC-related experiments
• The use and development of new 2D and 3D models
• The potential of iPSC-derived models in developing new therapeutic strategies
• The possibilities and limitations of iPSC-derived models