Neuroscience
New Horizons in Alzheimer's Disease (Hybrid edition)
27-28 October 2021, Virtual & Leuven, Belgium
New Horizons in Alzheimer's Disease (Hybrid edition)
New Horizons in Alzheimer's Disease (Hybrid edition)
Keep me postedAdd to calendar
Wim Annaert
Jean-Pierre Brion
Lucía Chávez Gutiérrez
Bart De Strooper
Ilse Dewachter
Rosa Rademakers
Patrik Verstreken
Roosmarijn Vandenbroucke
Evy Vierstraete
Alzheimer’s Disease research is accelerating with exciting new insights into molecular and cellular mechanisms. This upcoming conference brings together some of the thought leaders in the field with young investigators to stimulate discussion and interaction.
We anticipate further insights into the triangle amyloid, Tau and neuroinflammation and how these might provide novel therapeutic approaches.
The following topics will be the focus of this conference:
- Genes and environment
- Synapse and circuitry
- Mechanisms and models of disease
- Seeds and spreading of disease
Next to an inspiring scientific program, conference participants will have ample networking opportunities (both live and virtual) during the breaks, poster sessions and the conference dinner.
This conference is supported by:
Attending a VIB Conference safely in times of COVID-19
VIB Conferences will follow the rules set up by the Belgium Government, you can read all the details regarding attending a VIB Conference here.
What to expect from this hybrid event
The scientific program (presentations, Q&A’s, and poster sessions) will be available for both live and virtual audiences. The virtual platform also offers several ways of interacting with each other through (video) chat. On top of this there will be live poster presentations for those attending the event in Leuven. Talks will be recorded and made available after the event, with approval of the speakers.
Information for abstract submissions
The best thirteen abstracts were given a short talk slot in the plenary program. The deadline for poster presentations has passed. All accepted poster submissions will have a chance to win one of the two SAO Poster Prizes.
See also our sister meeting in Lille, France on October 25-26, 2021: http://eurotau.fr/
Confirmed speakers
Henrik Zetterberg
Henrik Zetterberg
University of Gothenburg, SE & UK Dementia Research Institute, UK
Maiken Nedergaard
Maiken Nedergaard
University of Rochester, Medical Center, US & University of Copenhagen, DK
Beth Stevens
Beth Stevens
Boston Children's Hospital; Broad Institute; Howard Hughes Medical Institute; Harvard University, US
Bart De Strooper
Bart De Strooper
VIB-KU Leuven Center For Neuroscience, BE & UK Dementia Research Institute, UK
Steven A. Goldman
Steven A. Goldman
University of Rochester, Medical Center, US & University of Copenhagen, DK
Henne Holstege
Henne Holstege
VIB-KU Leuven Center For Neuroscience, BE & Amsterdam University Medical Center, NL
Mathias Jucker
Mathias Jucker
The Hertie Institute for Clinical Brain Research (HIH) & German Center for Neurodegenerative Diseases (DZNE), DE
Jerome Mertens
Jerome Mertens
Salk Institute for Biological Studies, US & University of Innsbruck, AT
Tara Spires-Jones
Tara Spires-Jones
The University of Edinburgh & UK Dementia Research Institute, UK
Program
Day 1 - Wednesday, 27 October, 2021
Venue: KU Leuven Promotion & Jubileumzaal
Naamsestraat 22, 3000 Leuven. See practical info for more details.
08:30
08:50
Registration & Coffee
08:50
09:00
Welcome by Bart De Strooper
Session 1: Genes and environment
09:00
09:30
A central role for the blood-CSF interface and peripheral inflammation in Alzheimer's disease?
Roosmarijn Vandenbroucke
VIB-UGent Center for Inflammation Research, BE
09:30
10:00
Decoding microglia phenotypes in health and disease
Christopher Glass
University of California, San Diego, US
10:00
10:30
Learning from cognitively healthy centenarians to escape dementia
Henne Holstege
VIB-KU Leuven Center For Neuroscience, BE & Amsterdam University Medical Center, NL
10:30
10:40
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Nicola Fattorelli
VIB-KU Leuven Center For Neuroscience, BE
Selected from abstracts
10:40
10:50
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Sabina Tahirovic
German Center for Neurodegenerative Diseases (DZNE), DE
Selected from abstracts
Virtual presentation
10:50
11:20
Coffee break
11:20
11:50
Molecular basis of familial Alzheimer’s disease: insights into disease mechanisms and implications for therapeutics
Lucía Chávez Gutiérrez
VIB-KU Leuven Center For Neuroscience, BE
Sponsored by SAO
11:50
12:20
Modulation of Amyloid Deposition and Neuroinflammation by the Microbiome
Sangram S. Sisodia
Department of Neurobiology, University of Chicago, US
12:20
12:50
Glial disease and aging confer competitive disadvantage: A basis for cell replacement as a therapeutic strategy in neurodegenerative disorders
Steven A. Goldman
University of Rochester, Medical Center, US & University of Copenhagen, DK
12:50
13:00
New regulators of amyloid ß-peptide toxicity in Alzheimer’s disease
Francisco Muñoz
Universitat Pompeu Fabra, ES
Selected from abstracts
13:00
13:05
3D light sheet microscopy of entire mouse brain
Veerle Lemmens
Imaging Specialist BeNeLux Miltenyi Biotec, BE
Sponsored talk
13:05
13:45
Lunch
13:45
14:30
On-site poster session
Session 2: Synapse and circuitry
14:30
15:00
Novel insights into the role of the APP family in maintaining neural circuit function, with implications for AD therapy
Marc Aurel Busche
UK Dementia Research Institute at UCL, UK
15:00
15:30
SYNGO: defining the synapse and synaptic pathways in brain disease
Matthijs Verhage
Vrije Universiteit & Amsterdam University Medical Center, NL
15:30
16:00
Neural Basis of a Silent Alzheimer’s Disease Phase
Inna Slutsky
Tel Aviv University, IL
16:00
16:30
Coffee break
16:30
16:40
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
Pablo Largo Barrientos
VIB-KU Leuven Center For Neuroscience, BE & KU Leuven, Leuven Brain Institute, Mission Lucidity, BE
Selected from abstracts
16:40
16:50
Astrocytes and functional network disruptions at early stages of amyloid pathology
Disha Shah
VIB-KU Leuven Center For Neuroscience, BE
Selected from abstracts
16:50
17:00
In vivo assessment of synaptic pathology in dementia with SV2A-PET
Eric Salmon
University of Liege / GIGA Cyclotron Research Centre, BE
Selected from abstracts
17:00
17:30
Gamma oscillations: mechanisms, function and human diseases
Li-Huei Tsai
The Picower Institute for Learning and Memory & MIT, US
Virtual presentation
17:30
18:00
Imaging synaptic changes in Alzheimer’s disease
Tara Spires-Jones
The University of Edinburgh & UK Dementia Research Institute, UK
19:00
20:00
Keynote Lecture by Roger M. Nitsch at Kinepolis
This keynote is sponsored by SAO.
The discovery of aducanumab for the potential treatment of Alzheimer’s disease
Roger M Nitsch
CEO & President, Neurimmune, CH
Registration for this keynote is free, but mandatory, and separate from the conference ticket. Virtual conference attendees will not have to book this separately. For non-conference attendees you cannot watch the Nitsch lecture online, only on-site.
We will scan your COVID-certificate before entry to the lecture room, make sure to have your vaccination certificate QR code available.
20:15
22:30
Conference dinner at Kinepolis
For this dinner a separate ticket is required, which is available during the registration process. The dinner is only available to conference participants.
Day 2 - Thursday, 28 October, 2021
Venue: KU Leuven Promotion & Jubileumzaal
Naamsestraat 22, 3000 Leuven. See practical info for more details.
08:30
09:00
Welcome coffee
Session 3: Seeds and spreading of disease
09:00
09:30
Fluid biomarkers and their relation to Alzheimer brain pathology
Mathias Jucker
The Hertie Institute for Clinical Brain Research (HIH) & German Center for Neurodegenerative Diseases (DZNE), DE
09:30
10:00
New cell model for FTD tauopathy
Karen Duff
UK Dementia Research Institute at UCL, UK
10:00
10:30
Seeding and speading in tauopathies: mechanisms and therapeutic approaches
Luc Buée
University of Lille, Inserm, CHU-Lille, FR
10:30
10:35
Company talk: WuXi AppTec: Your partner for Alzheimer’s Disease drug discovery
Kris Rutten
Director, WuXi AppTec, NL
Sponsored talk
10:35
11:05
Coffee break
11:05
11:15
Heterotypic Abeta interactions facilitate amyloid assembly and modify amyloid structure
Frederic Rousseau
Switch Laboratory, VIB-KU Leuven Center For Neuroscience, BE
Selected from abstracts
11:15
11:25
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
Eliana Nachman
VIB-KU Leuven Center for Brain & Disease Research, BE
Selected from abstracts
11:25
11:35
Conformational strain diversity in misfolded amyloid beta peptides and potential repercussions in Alzheimer’s pathology
Rodrigo Morales
The University of Texas Health Science Center at Houston, US
Selected from abstracts
11:35
12:05
The Glymphatic System
Maiken Nedergaard
University of Rochester, Medical Center, US & University of Copenhagen, DK
12:05
12:35
The cellular phase of Alzheimer’s disease
Bart De Strooper
VIB-KU Leuven Center For Neuroscience, BE & UK Dementia Research Institute, UK
Sponsored by SAO
12:35
13:15
Lunch
13:15
14:00
Virtual poster session
Session 4: Mechanisms and models of disease
14:00
14:30
Beyond microglia: Temporal sequencing of perturbations in human cellular communities to establish the causal chain leading to aging-related cognitive decline
Philip L. De Jager
Columbia University Medical Center, US
14:30
15:00
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease
Anne Rovelet-Lecrux
University of Rouen, Inserm UMR1245, FR
15:00
15:30
Direct neuronal reprogramming to study aging and age-related neurodegeneration
Jerome Mertens
Salk Institute for Biological Studies, US & University of Innsbruck, AT
15:30
15:40
Combining pathogenic Tau pathways generates a super toxic Tau
Valerie Uytterhoeven
VIB-KU Leuven Center for Brain & Disease Research, BE
Selected from abstracts
15:40
15:50
Generation of non-human primate models of Alzheimer’s disease
Hiroki Sasaguri
RIKEN Center for Brain Science, JP
Selected from abstracts
Virtual presentation
15:50
16:20
Coffee break
16:20
16:30
Microglial contributions along the ATN axis in AD in preclinical models
Ilse Dewachter
Hasselt University, BE
Selected from abstracts
16:30
16:40
Developing human cellular models to understand biological mechanisms linked to AD genetic risk
Jessica Young
University of Washington, US
Selected from abstracts
Virtual presentation
16:40
17:10
Systemic regulation of brain function at the vasculature
Tony Wyss-Coray
Stanford University, US
Virtual presentation
17:10
17:40
Redefining Microglia States and Function in Alzheimer’s Disease
Beth Stevens
Boston Children's Hospital; Broad Institute; Howard Hughes Medical Institute; Harvard University, US
Virtual presentation
17:40
18:10
Update on fluid biomarkers for Alzheimer's disease
Henrik Zetterberg
University of Gothenburg, SE & UK Dementia Research Institute, UK
18:10
18:25
Poster prize ceremony and closing remarks
Organizing committee
Wim Annaert
VIB-KU Leuven Center For Neuroscience, BE
Jean-Pierre Brion
ULB Neuroscience Institute, BE
Lucía Chávez Gutiérrez
VIB-KU Leuven Center For Neuroscience, BE
Bart De Strooper
VIB-KU Leuven Center For Neuroscience, BE & UK Dementia Research Institute, UK
Ilse Dewachter
Hasselt University, BE
Rosa Rademakers
VIB-UAntwerp Center for Molecular Neurology, BE
Patrik Verstreken
VIB-KU Leuven Center For Neuroscience, BE
Roosmarijn Vandenbroucke
VIB-UGent Center for Inflammation Research, BE
Evy Vierstraete
VIB Training & Conferences, BE
Abstracts
The full list of abstracts will be available on 21-10-2021 until 12-11-2021
This list will only be available for registered attendees of the event.
This list will only be available for registered attendees of the event.
Attendees
The full list of attendees will be available on 21-10-2021 until 12-11-2021
This list will only be available for registered attendees of the event.
This list will only be available for registered attendees of the event.
Sponsors
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