Elise Dalmas obtained her Ph.D. in 2012 at Pierre and Marie Curie University (Paris, France), where she studied the role of interkeukin-1beta and the transcription factor Interferon Regulatory Factor (IRF)5 in adipose tissue macrophages during obesity and type 2 diabetes. During her postdoctoral studies at Basel University Hospital (Switzerland) with Prof. Marc Donath, she began her research into how resident immune cells influence pancreatic islet function during physiology and diabetes. Notably, she identified the first islet immuno-metabolic crosstalk orchestrated by mesenchymal cell-derived IL-33 and group 2 innate lymphoid cells to promote insulin secretion (Dalmas et al., Immunity, 2017). In 2017, Elise Dalmas moved back to Paris where she started setting up her research group at the French Institute of Health and Medical Research (INSERM). She continues exploring the concept that local immunity is part of the endocrine system and that resident immune cells contribute to islet adaptive responses to physiological metabolic stress.