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Chi Hongbo - VIB Conferences

Hongbo Chi

St. Jude Children's Research Hospital, US
Biography

Hongbo Chi, Ph.D. received his Ph.D. from the University of Rochester, and his postdoctoral training with Dr. Richard Flavell from Yale University School of Medicine. In 2007, he started his independent research program at St. Jude Children's Research Hospital, where he is currently a member (professor) in the Department of Immunology, and Robert G. Webster Endowed Chair in Immunology.

His research focuses on mechanisms of immune signaling and metabolism, in particular how mTOR and other signaling pathways interplay with metabolic programs in T cell fate decisions and dendritic cell biology. Among the highlights of the work, his laboratory has discovered the critical importance of mTOR signaling, metabolism and autophagy in the differentiation and function of effector and regulatory T cells, the control of T cell quiescence and antigen-triggered exit from quiescence, and the regulation of autoimmune, infectious and malignant diseases. More recently, his laboratory applies systems biology and immunology approaches, such as proteomics, metabolomics, single cell RNA-sequencing (scRNA-Seq), CRISPR screening and integrative network analysis, to reconstruct metabolic signaling circuits and identify new therapeutic targets in cancer and other immune-mediated diseases.

His work is highly regarded and widely referenced, earning him a place on the 2020 and 2021 Highly Cited Researchers lists. He has recently received an NIAID R37 merit award and an NCI outstanding investigator award.

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