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Philippe Jay

Institute of Functional Genomics, Montpellier, FR

Philippe Jay (Inserm, Montpellier, France) and his team are interested in the physiopathology of the intestinal epithelium, including the biology of intestinal stem cells and the function of several differentiated intestinal epithelial cell subsets. Recent work in this group led to the identification and characterisation of the tuft cell lineage in the intestinal epithelium. In the context of very limited information about intestinal tuft cells, and absence of tools allowing tuft cell-specific Cre or reporter expression in mice, the Jay team strongly invested in the study of these cells by generating new technology to enable their functional analysis. This resulted in the recent identification of the first function of the intestinal tuft cells in initiating the immune response to helminth parasites, in a collaborative effort by the Jay, Maizels and Taylor teams.

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