Franck Riquet is a tenured Associate Professor in Biology at Lille University (2009-present) where he developed his research line on biosensing of cellular processes in cellulo and in vivo. Since October 2013, he is also a Visiting Research Professor at Ghent University where he has established his research team in the unit Molecular Signaling of Cell Death of Prof. Peter Vandenabeele, to pioneer the study of spatio-temporal molecular features of necroptosis from cell culture to mice models for fundamental research and therapeutic purposes. (www.vib.be).
After his undergraduate and graduate studies conducted on Rheumatoid Arthritis in Dr. MB. Goldring’s laboratory at Harvard Medical School, Boston USA, he obtained his PhD in Molecular and Cellular Biology from Paris VII in 1999. Between 2000 and 2009, Franck Riquet worked as a scientist in different settings including academia in France and the US, biotech start-up and pharma in France. His experience is diverse, having led exploratory research projects related to cancer, metabolism, molecular virology and public health, and projects on cancer stem cells and cell adhesion dynamics.
Currently the Riquet team is interested in the regulation of cell death initiation namely the checkpoint between necroptosis and apoptosis at the RIPK1 level, and cell death execution at the level of MLKL and DFNA5. Specifically, the focus is on determining how signaling events are encoded and computed by the cell at the biochemical level. To this aim, quantitative single live cell imaging approaches are used to study key signal transduction effectors pattern, such as kinases, which dynamics are monitored via existing/optimized or newly developed genetically encoded reporters and FRET-based biosensors in living cells and tissues. The team masters in molecular biology and cellular biology and have expertise in many advanced live cell functional imaging techniques (FRAP, TIRF, FD/TD-FLiM) in live cells, tissues and aquatic animal models embryos.