Hidde Ploegh is a biochemist interested in questions of immunological relevance. He trained with Jack Strominger at Harvard University and has held positions at the University of Cologne (1980) and the Netherlands Cancer Institute (1984). He joined the MIT faculty in 1992, and in 1997 joined Harvard Medical School , where he directed the graduate program in immunology. In 2005 he returned to MIT at its Whitehead Institute. In 2016 he joined the Program in Cellular and Molecular Medicine at Boston Children's Hospital, where he continues to explore the properties and applications of nanobodies, including chemo-enzymatic approaches for their modification. His lab has focused on the conversion of nanobodies for imaging purposes (PET) and on their use for perturbation of protein-protein interactions.